Hearing after Congenital Deafness: Central Auditory Plasticity and Sensory Deprivation
نویسندگان
چکیده
منابع مشابه
Hearing after congenital deafness: central auditory plasticity and sensory deprivation.
The congenitally deaf cat suffers from a degeneration of the inner ear. The organ of Corti bears no hair cells, yet the auditory afferents are preserved. Since these animals have no auditory experience, they were used as a model for congenital deafness. Kittens were equipped with a cochlear implant at different ages and electro-stimulated over a period of 2.0-5.5 months using a monopolar single...
متن کاملDevelopment of a robust central auditory synapse in congenital deafness.
Within the medial nucleus of the trapezoid body (MNTB) in the auditory brain stem, there is a large central synapse known as the calyx of Held, which mediates high-fidelity glutamatergic transmission. We investigated the effects of congenital deafness on the development of pre- and postsynaptic parameters of synaptic strength at the calyx of Held. Whole cell recordings of evoked excitatory post...
متن کاملSensory Deprivation and Brain Plasticity
1 École d’Optométrie, Université de Montréal, Montréal, QC, Canada H3T 1P1 2Department of Neuroscience and Pharmacology, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark 3Danish Research Center for Magnetic Resonance, Hvidovre Hospital, DK-2650 Hvidovre, Denmark 4Department of Physiology and Pharmacology, The University of Western Ontario, London, ON, Canada N6A5K8 5Cen...
متن کاملInner Hair Cell Loss Disrupts Hearing and Cochlear Function Leading to Sensory Deprivation and Enhanced Central Auditory Gain
There are three times as many outer hair cells (OHC) as inner hair cells (IHC), yet IHC transmit virtually all acoustic information to the brain as they synapse with 90-95% of type I auditory nerve fibers. Here we review a comprehensive series of experiments aimed at determining how loss of the IHC/type I system affects hearing by selectively destroying these cells in chinchillas using the otot...
متن کاملDifferential activity in Heschl's gyrus between deaf and hearing individuals is due to auditory deprivation rather than language modality
Sensory cortices undergo crossmodal reorganisation as a consequence of sensory deprivation. Congenital deafness in humans represents a particular case with respect to other types of sensory deprivation, because cortical reorganisation is not only a consequence of auditory deprivation, but also of language-driven mechanisms. Visual crossmodal plasticity has been found in secondary auditory corti...
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ژورنال
عنوان ژورنال: Cerebral Cortex
سال: 2002
ISSN: 1460-2199
DOI: 10.1093/cercor/12.8.797